The paper published by Atkin and his co-authors on Plos One concluded that there was no evidence of adverse responses to aspartame, including in people who thought themselves sensitive to the sweetener.
This was not surprising. Aspartame is a simple, low calorie sweetener made from parts of protein. It is digested completely to common dietary components, which occur widely in food we consume as part of our daily diet, such as meat, fish, milk, fruit and vegetables. These components are treated by the body in just the same way, whether they come from aspartame or from other foods.
Of all the low calorie sweeteners, aspartame tastes most like sugar. By providing an excellent sweet taste without the calories of sugar, aspartame can help people avoid overweight and its consequences.